Dr. David Watkins Research Laboratory


  • Deeks, S. G. & Walker, B. D. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity 27, 406-416 (2007).
  • Goulder, P. J. & Watkins, D. I. HIV and SIV CTL escape: implications for vaccine design. Nat Rev Immunol 4, 630-640 (2004).
  • Migueles, S. A. & Connors, M. Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV. JAMA 304, 194-201 (2010).
  • Loffredo, J. T. et al. Mamu-B*08-positive macaques control simian immunodeficiency virus replication. J Virol 81, 8827-8832 (2007).
  • Loffredo, J. T. et al. Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity. J Immunol 182, 7763-7775 (2009).
  • Altfeld, M. et al. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T cell Response against HIV-1. PloSMed 3:e403 (2006).
  • Loffredo, J. T. et al. Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication. J Virol 82, 1723-1738 (2008).
  • Valentine, L. E. et al. Infection with “escaped” virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques. J Virol 83, 11514-11527 (2009).
  • Mudd, P.A. et al. Vaccine-induced CD8+ T cells control AIDS virus replication. Nature (Accepted, In Press) (2012).
  • Querec, T.D. et al. Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2,7, 8, and 9 to stimulate polyvalent immunity. J Exp Med 203: 413-424.
  • Querec, T.D. & Pulendrean, B. Understanding the role of innate immunity in the mechanisms of action of the live attenuated Yellow Fever Vaccine 17D. Adv Exp Med Biol 590:43-53 (2007).
  • Pulendran, B. Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology. Nat Rev Immunol 9:741-747 (2009).