Andrew V. Schally, Ph.D., MDhc (Multi), D.Sc
Clinical Specialties
Clinical trials with peptide analogs of LH-RH, bombesin/GRP, somatostatin and GHRH on a variety of cancers including prostate and breast cancer. Treatment of BPH with Cetrorelix, targeted chemotherapy.
Research Interests
Development and evaluation of peptide analogs with antitumor activity including targeted cytotoxic analogs of LHRH, somatostatin and bombesin and antagonistic analogs of GHRH
Inhibitory effects of peptide analogs on various cancers, including prostate cancer, pancreatic cancer, gastric cancer, colon cancer, malignant brain tumors, lung cancer (SCLC and non-SCLC), renal cancer and osteosarcomas, melanomas, hepatocellular carcinoma and lymphomas as well as breast cancers, ovarian cancers and endometrial cancers. Mechanism of action of GHRH antagonists and its receptors. Mechanism of action of LHRH antagonist Cetrorelix on BPH. Evaluation of hypothalamic peptide analogs in cardiology, diabetic nephropathy and Alzheimer's disease.
Awards & Recognition
- Ayerst-Squibb Award of the U.S. Endocrine Society
for special and outstanding research in the field of endocrinology, especially the isolation, determination of structure and synthesis of thyrotropin releasing hormone (TRH)
- William S. Middleton Award, the highest award in
the Veterans Administration, for outstanding achievement in medical research
- Charles Mickle Award of the Faculty of Medicine,
University of Toronto, for outstanding advances "of practical value in medical sciences," within the previous ten years,
- Gairdner Foundation International Award, Toronto, Canada,
for outstanding work on the identification, synthesis and clinical application of hypothalamic releasing hormones,
- Edward T. Tyler Award for contributions to the advancement
of medical knowledge in the field of human infertility and induction of ovulation
- Borden Award of the Association of American
Medical Colleges for outstanding research in medicine
- Albert Lasker Basic Medical Research Award of the
Albert and Mary Lasker Foundation, for contributions to the isolation, structure, determination and synthesis of hypothalamic hormones
- Nobel Prize in Physiology or Medicine
- Honorary Degrees, M.D.H.C., D.H.C., D.Sc.H.C.,
D.Nat.Sc.H.C. from 27 European and South American Universities
- The Heath Memorial Award from the M.D. Anderson
Cancer Center, Houston, Texas for development of new methods of cancer therapy (cancer patient care by the clinical application of basic cancer knowledge)
- Légion d'Honneur, Chevalier Grade, France,